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Identification of the Switch in Early-to-Late Endosome ,

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Sequential transport from early to late endosomes requires the coordinated activities of the small GTPases Rab5 and Rab7 The transition between early and late endosomes could be mediated either through transport carriers or by Rab conversion, a process in which the loss of Rab5 from an endosome occurs concomitantly to the acquisition of Rab7...

Rab5(Q79L) interacts with the carboxyl terminus of RUFY3

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Keywords: atherosclerosis, RUFY3, Rab5, RUN domain, protein interaction The small GTPase Rab5 controls the fusogenic properties of early endosomes through activation of effector proteins Expression of a GTPase-defective mutant, Rab5(Q79L), is known to cause formation of enlarged early endosom...

طراحی مکانیکی - [PDF Document]

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1 2 فھرست پيش گفتارنويسنده پيش گفتار مترجم طراحي -1 مقدمه 1- 1 فرايند طراحي 1- 2 طراحي جامع 1- 3 مشخصات,...

Rab5 Isoforms Differentially Regulate the Trafficking and ,

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Overexpressed Rab5 isoforms in cells have similar subcellular localization, suggesting that all three isoforms are properly targeted to membrane structures, and Rab5A is more active in EGFR trafficking pathway not because of better membrane association...

Rab5 (C8B1) Rabbit mAb - Cell Signaling Technology

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Background: Rab5 is a member of the Ras superfamily of small Rab GTPas Rab5 is localized at the plasma mem-brane and early endosomes and functions as a key regulator of vesicular trafficking during early endocytosis (1) The conformational change between Rab5 GTP/GDP states...

Rab5 Isoforms Differentially Regulate the Trafficking and ,

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Oct 30, 2009· Ligand-mediated endocytosis is an intricate regulatory mechanism for epidermal growth factor receptor (EGFR) signal transduction Coordinated trafficking of EGFR ensures its temporal and spatial communication with downstream signaling effectors...

Characterization of Rab5: Q79L-stimulated endosome fusion ,

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title = "Characterization of Rab5: Q79L-stimulated endosome fusion", abstract = "Fusion of intracellular membrane-bound compartments is a common step in the transport of macromolecules along the endocytic and secretory pathways...

RAB7A - Wikipedia

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Ras-related protein Rab-7a is a protein that in humans is encoded by the RAB7A gene Ras-related protein Rab-7a is involved in endocytosis, which is a process that brings substances into a cellThe process of endocytosis works by folding the cell membrane around a substance outside of the cell (for example a protein) and then forms a vesicleThe vesicle is then brought into the cell and ....

RAB5A - Wikipedia

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RAB5A localizes to early endosomes where it is involved in the recruitment of RAB7A and the maturation of these compartments to late endosom It drives the maturation of endosomes by transporting vacuolar (H+)-ATPases (V-ATPases) from trans-Golgi network to endocytic vesicl...

The complexity of Rab5 to Rab7 transition guarantees ,

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Simplified view of the molecular mechanisms involved in Rab5 to Rab7 transition exploited by bacterial pathogensRab5 in its active form recruits on the early compartment a GEF Rabex5, which stabilizes Rab5 recruitments to the membrane, and Vps34, the....

CST - Rab5 Antibody

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Rab5 exerts its function by interacting with several Rab5-specific effectors (1-3) These proteins form complexes with Rab5 on a specialized Rab domain of the endosome and promote recycling of Rab5-cargo targets between endosome and the plasma membrane...